AbstractPurpose:. The VISION trial of tepotinib, a selective MET inhibitor, enrolled patients with non–small cell lung cancer and prospectively detected MET exon 14 (METex14) skipping in liquid ...

Abstract. The integration of artificial intelligence (AI) in cancer research has significantly advanced radiology, pathology, and multimodal approaches, offering unprecedented capabilities in image ...

AbstractTo explore how early cancers can be detected prior to clinical signs or symptoms, we assessed prospectively collected serial plasma samples from the Atherosclerosis Risk in Communities study, ...

In the U.S., incidence rates of some cancers have increased in 15- to 49-year-olds with concomitant increases in older age groups, suggesting that changes in risk factor prevalence and/or improvements ...

To enhance the understanding of the tumor microenvironment of hepatocellular carcinoma, the authors employed an integrative single-cell analysis of posttranslational modifications, identifying ...

CTSMamba is a multitask deep learning model trained on longitudinal CT images of neoadjuvant chemotherapy-treated locally advanced gastric cancer that accurately predicts lymph node metastasis and ...

HRProfiler is a machine learning approach that reliably identifies homologous recombination deficiency in whole-exome–sequenced breast and ovarian cancers, outperforming other tools and providing ...

RAS inhibitors have shown early evidence of efficacy in multiple cancer types, but clinical benefit is limited by acquired resistance. Development of best-in-class inhibitors, with optimal potency, ...

Emerging spatial profiling technologies have revolutionized our understanding of how tissue architecture shapes disease progression, yet the contribution of cellular diversity remains underexplored.

Personalized vaccines can educate the immune system to recognize tumors. The authors report that in a first-in-human clinical trial, a personalized vaccine utilizing biomaterials (WDVAX) was safe, ...

The authors show that a subset of ATL cells and HTLV-1–infected T cells express DC–associated molecules. This transition to DC-like T cells evokes immune responses to viral antigens and is associated ...