The Function of Cumulus Cells in Oocyte Growth and Maturation …
WEBSep 2, 2021 · CCs that are in contact with the oocyte form the cumulus-oocyte complex (COC). This complex allows communication between the oocyte and CCs by directly affecting gene expression and protein synthesis, leading to differentiation and expansion of CCs as well as oocyte maturation.
Oocyte-cumulus cells crosstalk: New comparative insights
WEBJul 15, 2023 · In the antral follicle, a specialized subgroup of granulosa cells, the cumulus cells (CCs), surround and connect to the oocyte through the gap junction of transzonal projections [1], forming a structure called the cumulus–oocyte complex (COC).
human oocyte and cumulus cells relationship: new insights from …
WEBApr 29, 2010 · The mature cumulus oocyte complex (COC) is made up of the secondary oocyte, which is arrested at metaphase II following extrusion of the first polar body (PB), and surrounding cumulus cells (CCs). CCs possess highly specialized trans-zonal cytoplasmic projections that pierce through the zona pellucida and form gap junctions at their tips with ...
Transcriptomics of cumulus cells – a window into oocyte …
WEBAug 12, 2020 · The present sibling cumulus-oocyte-complex (COC) cohort study aimed at defining functional variations between oocytes of different maturity exposed to the same stimulation conditions, by assessing the transcriptomic signatures of their corresponding CC.
Unlocking the mysteries of the cumulus-oocyte complex—a …
WEBMar 12, 2019 · Structural and functional communications within the cumulus-oocyte complex (COC) are essential for gradual acquisition of oocyte developmental competence during folliculogenesis, and to ensure the occurrence of meiosis resumption after the LH peak, when the activation of the ovulatory cascade triggers final oocyte maturation in vivo.
Intercellular communication in the cumulus–oocyte complex …
WEBJan 19, 2023 · During folliculogenesis, the oocyte and surrounding cumulus cells form an ensemble called the cumulus-oocyte complex (COC). Due to their interdependence, research on the COC has been a hot issue in the past few decades.
Metabolic co-dependence of the oocyte and cumulus cells: …
WEBOct 6, 2020 · In the last decade, there has been significant progress in understanding the metabolism of the cumulus–oocyte complex (COC) during its final stages of growth and maturation in the follicle. Certain metabolic conditions (e.g. obesity) or ART (e.g. IVM) perturb COC metabolism, providing insights into metabolic regulation of oocyte quality.
The Function of Cumulus Cells in Oocyte Growth and Maturation …
WEBSep 2, 2021 · Abstract. Cumulus cells (CCs) originating from undifferentiated granulosa cells (GCs) differentiate in mural granulosa cells (MGCs) and CCs during antrum formation in the follicle by the distribution of location. CCs are supporting cells of the oocyte that protect the oocyte from the microenvironment, which helps oocyte growth and …
The Function of Cumulus Cells in Oocyte Growth and Maturation …
WEBSep 2, 2021 · CCs that are in contact with the oocyte form the cumulus-oocyte complex (COC). This complex allows communication between the oocyte and CCs by directly affecting gene expression and protein synthesis, leading to differentiation and expansion of CCs as well as oocyte maturation.
Cyclic AMP-elevating Agents Promote Cumulus Cell Survival and ...
WEBCumulus cells sustain the development and fertilization of the mammalian oocyte. These cells are retained around the oocyte by a hyaluronan-rich extracellular matrix synthesized before ovulation, a process called cumulus cell-oocyte complex (COC) expansion.